Name | 2-(2-Ethoxyethoxy)ethanol |
Synonyms | APV DECS dowanol dioxitol Carbitol diglycol solvolsol transcutol dowanol de ethyl digol poly-solv de ektasolve de o-ethyldigol Ethyl Carbitol ethoxy diglycol -2-Ethoxyethoxy losungsmittel apv 3,6-dioxa-1-octanol 3,6-Dioxa-1-octanol 3,6-Dioxa-1-oktanol 3,6-Dioxaoctan-1-ol 3,6-dioxaoctan-1-ol Carbitol cellosolve carbitol cellosolve aethyldiaethylenglycol ethyl diethylene glycol 2-(ethoxyethoxy)ethanol 2(2-Ethoxyethoxy)ethanol diglycol monoethyl ether 2-(2-Ethoxyethoxy)ethanol 1-hydroxy-3,6-dioxaoctane 2-(beta-ethoxyethoxy)ethanol Diethylene glycol ethyl ether 3-Oxapentane-1,5-diolethylether 2,2'-oxybis-ethanomonoethylether Diethylene Glycol Monoethyl Ether ethylene diglycol monoethyl ether monoethyl ether of diethylene glycol ethanol, 2,2'-oxybis-, monoethyl ether Ethoxydiglycol |
CAS | 111-90-0 |
EINECS | 203-919-7 |
InChI | InChI=1/C4H10O3.C4H10O/c5-1-3-7-4-2-6;1-3-5-4-2/h5-6H,1-4H2;3-4H2,1-2H3 |
InChIKey | XXJWXESWEXIICW-UHFFFAOYSA-N |
Molecular Formula | C6H14O3 |
Molar Mass | 134.17 |
Density | 0.999g/mLat 25°C(lit.) |
Melting Point | -80 °C |
Boling Point | 202°C(lit.) |
Flash Point | 205°F |
Water Solubility | Miscible |
Solubility | It is miscible in acetone, benzene, chloroform, ethanol and ether. |
Vapor Presure | 0.12 mm Hg ( 20 °C) |
Vapor Density | 4.63 (vs air) |
Appearance | Colorless transparent liquid |
Color | Clear colorless |
Odor | Weakly fruity; mild and characteristic. |
Merck | 14,1800 |
BRN | 1736441 |
pKa | 14.37±0.10(Predicted) |
Storage Condition | Store below +30°C. |
Stability | Stable. Combustible. Note wide explosion limits. Incompatible with strong oxidizing agents, strong acids, acid chlorides, acid anhydrides. Hygroscopic. |
Sensitive | Hygroscopic |
Explosive Limit | 1.8-12.2%(V) |
Refractive Index | n20/D 1.427(lit.) |
MDL | MFCD00002872 |
Physical and Chemical Properties | Properties of colorless, stable water absorption liquid, flammable. There is a moderate pleasant smell, slightly sticky. The solubility is miscible with water, acetone, benzene, chloroform, ethanol, diethyl ether, pyridine, etc. |
Use | Mainly used for mutual solvent in paint and ink |
Risk Codes | R36 - Irritating to the eyes R20 - Harmful by inhalation R36/37/38 - Irritating to eyes, respiratory system and skin. |
Safety Description | S23 - Do not breathe vapour. S24/25 - Avoid contact with skin and eyes. S39 - Wear eye / face protection. S26 - In case of contact with eyes, rinse immediately with plenty of water and seek medical advice. S36 - Wear suitable protective clothing. |
WGK Germany | 1 |
RTECS | KK8750000 |
TSCA | Yes |
HS Code | 29094400 |
Toxicity | LD50 orally in rats: 8.69 g/kg (Smyth, Carpenter) |
Raw Materials | Ethylene Oxide Ethyl Alcohol |
Reference Show more | 1. Hu Chunli, Yang Beibei, Zhang Linjie, et al. Preparation and Quality Control of Lutein Self-microemulsion [J]. Today's Pharmaceutical 2019(9). 2. Wu, JY., Cai, JX., Li, YJ. et al. 3,5,4 '-Trimethoxy-trans-stilbene loaded microemulsion for cutaneous melanoma therapy by transdermal drug delivery. Drug Deliv. and Transl. Res. 11, 169-181 (2021). https://doi.org/10.1007/s13346-020-00757-w 3. [IF = 4.617] Wu Jun-Yong et al."3,5,4'-Trimethoxy-trans-stilbene loaded microemulsion for cutaneous melanoma therapy by transdermal drug delivery." Drug Deliv Transl Re. 2021 Feb;11(1):169-181 |
colorless, water-absorbent stable liquid. Flammable. There is a moderate pleasant smell. Slightly sticky. The relative density was 0. 9898. Boiling point 202.7 C (195 C). Vapor pressure (20 °c)<130Pa. Melting Point -78 °c (vitreous)(-25 °c). Viscosity (20 deg C) 4.5mPa.s. Refractive index 1. 4273 (4300). Molar heat of vaporization 47. lOkj/mol. Flash point (Open Cup) 96.1 °c. With water, acetone, benzene, chloroform, ethanol, ether, pyridine and other miscible.
can be used as cellulose, resin, gum, paint, paint and other solvents, printing ink solvent, mineral oil-soap and mineral oil-vulcanized oil mixture of mutual solvent, non-paint colorant, fiber printing agents, varnishes and paint diluents.
has inhibitory effect on the central nervous system. Rat oral LD50 8690mg/kg. Avoid long-term contact with the skin. Operators should wear anti-virus masks to avoid long-term inhalation.
Glass bottle packaging, external use of wooden cases reinforcement, anti-impact, anti-heat, fire. The flammable and toxic substances shall be stored and transported according to the regulations.
LogP | -0.54 at 20℃ |
NIST chemical information | Information provided by: webbook.nist.gov (external link) |
EPA chemical information | Information provided by: ofmpub.epa.gov (external link) |
toxicity | ADI is not specified (FAO/WHO,2001). |
use | mainly used for mutual solvents in paints and inks carrier solvents. (mainly used in Islamic countries as an ethanol substitute for citrus flavors). This product is a high boiling point solvent. Solvents for cellulose, resins, gums, coatings, printing inks, dyes, mutual solvents for mineral oil-soap and mineral oil-sulfurized oil mixtures, non-paint colorants, fiber printing agents, thinners for varnishes and paints. Used as a solvent, also used for varnish and plastic preparation solvent. Organic synthesis. |
Production method | 1. Ethylene oxide method First add anhydrous ethanol, boron trifluoride-ether solution to the reactor, and then add ethylene oxide. When the reaction temperature rises to 45 ℃, it is cooled and the reaction temperature is controlled below 70 ℃. After the reaction is completed, the finished product is obtained by neutralization and decompression distillation, and the fraction below 90 ℃(0.1MPa) is collected. 2. Diethylene glycol method is prepared by the reaction of diethylene glycol and diethyl sulfate. It is formed by the condensation of diethylene glycol and 1 molecule of ethanol. |
category | combustible liquid |
toxicity classification | low toxicity |
acute toxicity | oral-rat LD50: 5500 mg/kg; Oral-mouse LD50: 6600 mg/kg |
stimulation data | skin-rabbit 500 mg/24 hours mild; Eye-rabbit 125 mg mild |
flammability hazard characteristics | combustible in case of open flame, high temperature and strong oxidant; Combustion emission stimulates smoke |
storage and transportation characteristics | complete packaging, light loading and unloading; warehouse ventilation, away from open flames, high temperature, separate storage from oxidant |
fire extinguishing agent | foam, dry powder, carbon dioxide |
spontaneous combustion temperature | 204°C |
toxic substance data | information provided by: pubchem.ncbi.nlm.nih.gov (external link) |